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Dattilo M, Fontanarosa C, Spinelli M, Bini V, Amoresano A

The critical insight from clinical data is that relatively few participants discontinued tirzepatide due to side effects

10.1016/j.phymed.2021.153489 30 ChiangH.-M.LinJ.-W.HsiaoP.-L.TsaiS.-Y.WenK.-C

When cytoplasmic concentrations of neurotransmitters rise dangerously high, TAAR1 activates G-protein-dependent signaling pathways that recruit intracellular kinases, including protein kinase C (PKC) and calcium/calmodulin-dependent protein kinase II (CaMKII) (Underhill et al., 2020)

The most common side effect described, with respect to the total number of related topics, groups, and discussions, was nausea, followed by vomiting, constipation, injection site issues, pancreatitis, and gastroparesis